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35,83,87,112,117,120,156,242,251280 Most activators enhance mitochondrial function and fatty acid -oxidation via the SIRT1PGC-1 axis while inhibiting lipid synthesis mediated by SREBP-1c and ChREBP and positively modulating inflammatory and oxidative pathways such as FOXO1 and NF-B

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These systemic improvements correlate with reduced infection susceptibility and enhanced immune surveillance capacity in aged individuals